Anti-Aging & Longevity
Epitalon
Epitalon (epithalamin tetrapeptide)
Tetrapeptide developed for telomerase activation and longevity
- FDA Status
- Not FDA-approved · Used in Russian gerontology
- Class
- Tetrapeptide · pineal gland-derived
- Sequence
- Ala-Glu-Asp-Gly
- Half-life
- Short (~30 min) · cumulative effect via gene expression
Mechanism of action
- Telomerase activity stimulation in some cell lines
- Pineal gland function modulation
- Melatonin secretion regulation
- Gene expression modulation in aging-related pathways
Research areas
- Telomere length and cellular aging
- Sleep cycle regulation (pineal pathway)
- Melanoma protection (animal data)
- Geriatric studies in Russian institutes
Evidence and clinical data
Russian longitudinal data from Khavinson group. Reduced age-related mortality in observational cohorts. No Western Phase III data. Mechanism remains debated.
Safety profile
No significant adverse events in Russian observational data over 25+ years. Western pharmacovigilance limited.
Why this peptide is trending in 2026: Anchor peptide of the longevity community. Often discussed alongside David Sinclair-style anti-aging interventions.
Educational use only. PeptideAdvance does not sell Epitalon, recommend its use, or provide medical advice. The information above is a summary of published research and regulatory status as of April 2026. Some peptides discussed here are not FDA-approved or are restricted under FDA Category 2 — their use outside of authorized clinical research may carry legal and safety implications. Always consult a licensed healthcare professional.